The Pace of Change

Jun 27 2011 Published by under Uncategorized

For at least a decade it has been recommended that the isoforms of nitric oxide synthase (NOS) be indicated by number, not letter. Brain or neuronal NOS should be 1, inducible NOS 2, and endothelial NOS 3. These isoforms were named for the situation or tissue in which they were initially identified. Like many such things in science, over time it became clear that nNOS and eNOS existed in other tissues, and that iNOS was expressed under baseline conditions, not just after induction.

Yet today, in 2011, I continue to hear about lettered NOS in multiple sessions at a scientific meeting. What will it take to change behavior? NOS police with stun guns? Abbreviation linebackers?

What makes you change the way you label something? It only took a couple of reviewers correcting me to change my ways.

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